Recent CBC coverage highlighted the financial barriers Canadians face accessing daraxonrasib, an investigational pancreatic cancer treatment. One Canadian patient reportedly faces costs of approximately $90,000 per month to access the drug in the United States, while another shared her status on a clinical trial waitlist.

At Craig’s Cause Pancreatic Cancer Society, we believe promising treatments must be matched by faster, more equitable access to care. Using our Clinical Trials Finder, we’ve compiled information on three clinical trials involving daraxonrasib currently listed in Canada.

Do you have a RAS mutation?

Daraxonrasib is being studied in pancreatic cancer, and eligibility depends on the specific clinical trial. Molecular testing is important because it can help identify which treatments and clinical trials you may be eligible for. Ask your oncologist whether your tumour has been tested for genetic changes, including RAS mutations. This is usually done through tumour molecular profiling or, in some cases, a blood test called a liquid biopsy.

What clinical trials are available?

These trials have sites in Vancouver, Toronto and Montreal. Each has different eligibility requirements.

1. NCT07491445 — First-line treatment for metastatic pancreatic cancer

• Locations: Montreal and Toronto
• Status: Recruiting
• Eligibility: Patients with untreated metastatic pancreatic cancer.

This trial compares daraxonrasib alone, daraxonrasib combined with chemotherapy, and standard chemotherapy. Participation does not guarantee receiving daraxonrasib.

View trial details and eligibility criteria

2. NCT07492680 — Combination treatment for metastatic pancreatic cancer

• Locations: Vancouver and Toronto
• Status: Not yet recruiting
• Eligibility: Patients with untreated metastatic pancreatic cancer and an MTAP deletion, a specific genetic change.

This trial studies combination treatments; not every participant will necessarily receive daraxonrasib.

View trial details and eligibility criteria

3. NCT07252232 — Treatment after pancreatic cancer surgery

• Locations: Montreal and Toronto
• Status: Recruiting
• Eligibility: Patients who have undergone surgery to remove pancreatic cancer and completed the required chemotherapy.

This trial investigates whether daraxonrasib after surgery and chemotherapy can help prevent cancer from returning. Patients planning surgery may discuss eligibility with their care team, but enrolment depends on meeting the study requirements.

View trial details and eligibility criteria

Trial status and eligibility can change. Consult the official listings for current information.

How can patients explore these trials?

If you’re interested in a clinical trial, bring this blog to your oncologist or cancer care team. They can help you understand the eligibility criteria, determine whether a referral is appropriate, and discuss other potential treatment or clinical trial options.

A referral does not guarantee acceptance, as each trial has its own screening process.

Travel considerations & financial support

There are currently no listed sites for these three trials in Atlantic Canada or the Prairie provinces. Patients in these regions may need to travel to Montreal, Toronto or Vancouver, facing additional costs for transportation, accommodation and time away from family or work. Travel assistance varies by trial, so ask the study team what support may be available.

Craig’s Cause Pancreatic Cancer Society also offers Patient Financial Support Grants to help eligible patients facing financial challenges. Click here to apply.

Access must be more equitable

Accessing a promising treatment should not depend on where someone lives or what they can afford. These trials offer potential opportunities, but geographic and financial barriers can make participation difficult for many Canadians.

Donations help us support patients facing these barriers while advocating for faster, more equitable access to care. Continued support allows us to help patients navigate difficult circumstances and push for a future where access to promising treatments is not determined by postal code or financial circumstances.

Explore Canadian clinical trials using our Clinical Trials Finder.

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